RGS9BP

Regulator of G protein signaling 9 binding protein is a protein that in humans is encoded by the RGS9BP gene. ^[5]

RGS9BP
Identifiers
Aliases	RGS9BP, regulator of G protein signaling 9 binding protein, PERRS, R9AP, RGS9, regulator of G-protein signaling 9 binding protein
External IDs	OMIM: 607814; MGI: 2384418; HomoloGene: 17113; GeneCards: RGS9BP; OMA:RGS9BP - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.11 Start 32,675,848 bp[1] End 32,678,300 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B2 Start 35,278,418 bp[2] End 35,285,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle muscle of thigh gastrocnemius muscle apex of heart skeletal muscle tissue retinal pigment epithelium left ventricle right auricle of heart prefrontal cortex stromal cell of endometrium Top expressed in neural layer of retina epithelium of lens retinal pigment epithelium pineal gland ciliary body outer nuclear layer iris transitional epithelium of urinary bladder esophagus conjunctival fornix More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 388531 243923 Ensembl ENSG00000186326 ENSMUSG00000056043 UniProt Q6ZS82 Q148R9 RefSeq (mRNA) NM_207391 NM_145840 RefSeq (protein) NP_997274 NP_665839 Location (UCSC) Chr 19: 32.68 – 32.68 Mb Chr 7: 35.28 – 35.29 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia.