RHBDF2

Inactive rhomboid protein 2 is a protein that in humans is encoded by the RHBDF2 gene.^[5][6] The alternative name iRhom2 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.^[7][8]

RHBDF2
Identifiers
Aliases	RHBDF2, RHBDL5, RHBDL6, TOC, TOCG, TEC, iRhom2, rhomboid 5 homolog 2
External IDs	OMIM: 614404; MGI: 2442473; HomoloGene: 11612; GeneCards: RHBDF2; OMA:RHBDF2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,470,891 bp[1] End 76,501,790 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 116,488,991 bp[2] End 116,517,845 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte spleen sural nerve blood lymph node skin of leg skin of abdomen upper lobe of left lung C1 segment Top expressed in granulocyte secondary oocyte lip muscle of thigh bone marrow mesenteric lymph nodes spleen zygote primary oocyte left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function serine-type endopeptidase activity growth factor binding protein binding peptidase activity hydrolase activity Cellular component integral component of membrane endoplasmic reticulum membrane plasma membrane endoplasmic reticulum membrane Biological process protein transport protein processing regulation of epidermal growth factor receptor signaling pathway proteolysis regulation of protein secretion negative regulation of protein secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79651 217344 Ensembl ENSG00000129667 ENSMUSG00000020806 UniProt Q6PJF5 Q80WQ6 RefSeq (mRNA) NM_001005498 NM_024599 NM_001376228 NM_001376229 NM_001376230 NM_001167680 NM_172572 RefSeq (protein) NP_001005498 NP_078875 NP_001363157 NP_001363158 NP_001363159 NP_001161152 NP_766160 NP_001390556 NP_001390557 Location (UCSC) Chr 17: 76.47 – 76.5 Mb Chr 11: 116.49 – 116.52 Mb PubMed search [3] [4]
Wikidata
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The RHBDF2 gene is located on the long arm of chromosome 17 (17q25.1) on the Crick (minus) strand. It is 30.534 kilobases in length and encodes a protein of 856 amino acids with a predicted molecular weight of 96.686 kilodaltons.

The RHBDF2 protein plays an important role in the secretion of tumor necrosis factor alpha,^[9][10][11] and has also been implicated in familial esophageal cancer.^[12]

It is involved in the regulation of the secretion of several ligands of the epidermal growth factor receptor.^[13]