RIMS2

Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene.^[4][5][6]

RIMS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V27, 1WFG
Identifiers
Aliases	RIMS2, OBOE, RAB3IP3, RIM2, regulating synaptic membrane exocytosis 2
External IDs	OMIM: 606630; MGI: 2152972; HomoloGene: 81639; GeneCards: RIMS2; OMA:RIMS2 - orthologs
Gene location (Mouse) Chr. Chromosome 15 (mouse)[1] Band 15 B3.1|15 15.45 cM Start 39,061,656 bp[1] End 39,547,768 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in Rostral migratory stream neural layer of retina lateral geniculate nucleus medial dorsal nucleus cerebellar vermis lobe of cerebellum inferior colliculi nucleus accumbens lateral septal nucleus medial geniculate nucleus BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding transmembrane transporter binding Cellular component membrane plasma membrane synapse intracellular anatomical structure presynaptic active zone cell junction extracellular exosome presynaptic membrane cytoskeleton of presynaptic active zone presynaptic active zone cytoplasmic component Biological process cell differentiation spontaneous neurotransmitter secretion positive regulation of inhibitory postsynaptic potential insulin secretion regulation of exocytosis positive regulation of gene expression positive regulation of excitatory postsynaptic potential positive regulation of dendrite extension intracellular protein transport cAMP-mediated signaling calcium-ion regulated exocytosis regulation of membrane potential calcium ion-regulated exocytosis of neurotransmitter regulation of synaptic vesicle exocytosis exocytosis regulation of synaptic plasticity positive regulation of synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9699 116838 Ensembl ENSG00000176406 ENSMUSG00000037386 UniProt Q9UQ26 Q9EQZ7 RefSeq (mRNA) NM_001100117 NM_001282881 NM_001282882 NM_014677 NM_001256382 NM_001256383 NM_001256384 NM_053271 RefSeq (protein) NP_001093587 NP_001269810 NP_001269811 NP_055492 NP_001335413 NP_001335414 NP_001335415 NP_001335416 NP_001335417 NP_001335418 NP_001335419 NP_001335420 NP_001335421 NP_001335422 NP_001335423 NP_001335424 NP_001335425 NP_001335426 NP_001335427 NP_001335428 NP_001335429 NP_001335430 NP_001335431 NP_001335432 NP_001335433 NP_001335434 NP_001335435 NP_001335436 NP_001335437 NP_001335438 NP_001243311 NP_001243312 NP_001243313 NP_444501 Location (UCSC) n/a Chr 15: 39.06 – 39.55 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RIMS2 has been shown to interact with YWHAH,^[7] RAPGEF4,^[8][9] and UNC13A.^[10]