RIN1

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.^[5][6][7]

RIN1
Identifiers
Aliases	RIN1, Ras and Rab interactor 1
External IDs	OMIM: 605965; MGI: 2385695; HomoloGene: 3170; GeneCards: RIN1; OMA:RIN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 66,330,241 bp[1] End 66,336,840 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,100,509 bp[2] End 5,107,099 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland tendon of biceps brachii olfactory bulb right hemisphere of cerebellum skin of leg skin of abdomen vena cava nucleus accumbens putamen external globus pallidus Top expressed in nucleus accumbens superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell dorsal striatum hippocampus proper prefrontal cortex olfactory tubercle amygdala spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm plasma membrane cytoskeleton membrane cytosol dendrite soma Biological process positive regulation of GTPase activity endocytosis signal transduction memory associative learning negative regulation of synaptic plasticity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9610 225870 Ensembl ENSG00000174791 ENSMUSG00000024883 UniProt Q13671 Q921Q7 RefSeq (mRNA) NM_004292 NM_001363559 NM_001363560 NM_145495 NM_001374051 NM_001374052 RefSeq (protein) NP_004283 NP_001350488 NP_001350489 NP_663470 NP_001360980 NP_001360981 Location (UCSC) Chr 11: 66.33 – 66.34 Mb Chr 19: 5.1 – 5.11 Mb PubMed search [3] [4]
Wikidata
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Interactions

RIN1 has been shown to interact with HRAS.^[8][9]

Additionally, RIN1 binds and activates ABL family tyrosine kinases.