RNASEH1

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene.^[5][6][7] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.

RNASEH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QK9, 2QKB, 2QKK, 3BSU
Identifiers
Aliases	RNASEH1, H1RNA, RNH1, PEOB2, ribonuclease H1
External IDs	OMIM: 604123; MGI: 1335073; HomoloGene: 2202; GeneCards: RNASEH1; OMA:RNASEH1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.3 Start 3,541,430 bp[1] End 3,558,333 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A2 Start 28,699,601 bp[2] End 28,709,588 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell middle temporal gyrus nipple visceral pleura parietal pleura Skeletal muscle tissue of biceps brachii tibia Brodmann area 23 gonad Top expressed in Paneth cell primary oocyte saccule otic placode otic vesicle secondary oocyte neural layer of retina primitive streak zygote morula More reference expression data BioGPS n/a
Gene ontology Molecular function nuclease activity endonuclease activity RNA-DNA hybrid ribonuclease activity ribonuclease activity hydrolase activity magnesium ion binding metal ion binding RNA binding nucleic acid binding Cellular component cytoplasm nucleus Biological process nucleic acid phosphodiester bond hydrolysis RNA catabolic process DNA replication, removal of RNA primer RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 246243 19819 Ensembl ENSG00000171865 ENSMUSG00000020630 UniProt O60930 E9QLN8 RefSeq (mRNA) NM_001286834 NM_001286837 NM_002936 NM_001378271 NM_001378272 NM_001378273 NM_001286865 NM_011275 RefSeq (protein) NP_001273763 NP_001273766 NP_002927 NP_001365200 NP_001365201 NP_001365202 NP_001273794 NP_035405 Location (UCSC) Chr 2: 3.54 – 3.56 Mb Chr 12: 28.7 – 28.71 Mb PubMed search [3] [4]
Wikidata
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