RNASET2

Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene.^[5][6] It is a type of endoribonuclease.

RNASET2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T0O
Identifiers
Aliases	RNASET2, RNASE6PL, bA514O12.3, ribonuclease T2
External IDs	OMIM: 612944; MGI: 3702087; HomoloGene: 31190; GeneCards: RNASET2; OMA:RNASET2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 166,922,113 bp[1] End 166,957,191 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A1 Start 7,238,033 bp[2] End 7,278,698 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube granulocyte blood monocyte spleen parotid gland seminal vesicula olfactory bulb lymph node inferior ganglion of vagus nerve Top expressed in right kidney granulocyte muscle of thigh lip zygote esophagus genital tubercle dentate gyrus of hippocampal formation granule cell ventricular zone morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity ribonuclease T2 activity endonuclease activity nuclease activity RNA binding ribonuclease activity endoribonuclease activity Cellular component lysosomal lumen endoplasmic reticulum lumen lysosome endoplasmic reticulum extracellular exosome extracellular region extracellular space azurophil granule lumen Biological process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic RNA catabolic process RNA phosphodiester bond hydrolysis neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8635 68195 Ensembl ENSG00000026297 ENSMUSG00000094724 UniProt O00584 Q5FWA0 RefSeq (mRNA) NM_003730 NM_017795 NM_018726 NM_026611 NM_029204 RefSeq (protein) NP_003721 NP_080887 NP_001077407 NP_080887 Location (UCSC) Chr 6: 166.92 – 166.96 Mb Chr 17: 7.24 – 7.28 Mb PubMed search [3] [4]
Wikidata
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This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.^[6] RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas.^[7]