RNF111

E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.^[5][6]

RNF111
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KIZ
Identifiers
Aliases	RNF111, ARK, ring finger protein 111, hRNF111
External IDs	OMIM: 605840; MGI: 1934919; HomoloGene: 9741; GeneCards: RNF111; OMA:RNF111 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.1-q22.2 Start 58,865,175 bp[1] End 59,097,419 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 39.53 cM Start 70,332,706 bp[2] End 70,411,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell monocyte ganglionic eminence Epithelium of choroid plexus ventricular zone epithelium of colon stromal cell of endometrium tonsil sural nerve Top expressed in zygote cumulus cell secondary oocyte granulocyte primitive streak blood parotid gland pineal gland lymph node aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SUMO polymer binding protein binding metal ion binding ubiquitin protein ligase activity transferase activity SMAD binding Cellular component nucleoplasm nucleus cytoplasm cytosol PML body protein-containing complex Biological process positive regulation of transcription, DNA-templated ubiquitin-dependent SMAD protein catabolic process protein polyubiquitination multicellular organism development positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein ubiquitination pattern specification process proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination global genome nucleotide-excision repair positive regulation of transcription by RNA polymerase II DNA repair cellular response to DNA damage stimulus ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54778 93836 Ensembl ENSG00000157450 ENSMUSG00000032217 UniProt Q6ZNA4 Q99ML9 RefSeq (mRNA) NM_001270528 NM_001270529 NM_001270530 NM_017610 NM_001330331 NM_033604 NM_001357494 NM_001374753 RefSeq (protein) NP_001257457 NP_001257458 NP_001257459 NP_001317260 NP_060080 NP_291082 NP_001344423 NP_001361682 Location (UCSC) Chr 15: 58.87 – 59.1 Mb Chr 9: 70.33 – 70.41 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.^[6]

Interactions

RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7^[7] and Mothers against decapentaplegic homolog 3.^[7][8]