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RNF12

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

RNF12
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E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[5][6]

Quick Facts RLIM, Identifiers ...
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Function

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[6] Functions in female mice as a regulator of X chromosome inactivation .

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Interactions

RNF12 has been shown to interact with Estrogen receptor alpha.[7]

References

Further reading

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