Top Qs
Timeline
Chat
Perspective
RNF12
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Remove ads
E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[5][6]
Remove ads
Function
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[6] Functions in female mice as a regulator of X chromosome inactivation .
Remove ads
Interactions
RNF12 has been shown to interact with Estrogen receptor alpha.[7]
References
Further reading
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads