RNF12

E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.^[5][6]

RLIM
Identifiers
Aliases	RLIM, NY-REN-43, RNF12, ring finger protein, LIM domain interacting, MRX61, TOKAS
External IDs	OMIM: 300379; MGI: 1342291; HomoloGene: 7920; GeneCards: RLIM; OMA:RLIM - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.2 Start 74,582,976 bp[1] End 74,614,624 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X 46.42 cM|X D Start 103,000,769 bp[2] End 103,024,890 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus cartilage tissue Achilles tendon Brodmann area 46 postcentral gyrus internal globus pallidus entorhinal cortex Brodmann area 23 tendon of biceps brachii pars compacta Top expressed in gastrula cumulus cell internal carotid artery zygote Gonadal ridge external carotid artery ectoderm otic vesicle Rostral migratory stream otic placode More reference expression data BioGPS n/a
Gene ontology Molecular function transcription corepressor activity metal ion binding transferase activity ubiquitin-protein transferase activity ubiquitin protein ligase activity protein binding Cellular component transcription repressor complex nucleus cytosol nucleoplasm Biological process negative regulation of transcription, DNA-templated transcription, DNA-templated protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II ubiquitin-dependent protein catabolic process negative regulation of DNA-binding transcription factor activity random inactivation of X chromosome regulation of dosage compensation by inactivation of X chromosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51132 19820 Ensembl ENSG00000131263 ENSMUSG00000056537 UniProt Q9NVW2 Q9WTV7 RefSeq (mRNA) NM_183353 NM_016120 NM_011276 NM_001358205 RefSeq (protein) NP_057204 NP_899196 NP_035406 NP_001345134 Location (UCSC) Chr X: 74.58 – 74.61 Mb Chr X: 103 – 103.02 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.^[6] Functions in female mice as a regulator of X chromosome inactivation .

Interactions

RNF12 has been shown to interact with Estrogen receptor alpha.^[7]