RNF123

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.^[5]

RNF123
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA6
Identifiers
Aliases	RNF123, KPC1, FP1477, ring finger protein 123
External IDs	OMIM: 614472; MGI: 2148796; HomoloGene: 11112; GeneCards: RNF123; OMA:RNF123 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,689,538 bp[1] End 49,721,529 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 107,928,733 bp[2] End 107,960,545 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle vastus lateralis muscle Skeletal muscle tissue of rectus abdominis right lobe of liver triceps brachii muscle body of tongue biceps brachii Skeletal muscle tissue of biceps brachii thoracic diaphragm Top expressed in neural layer of retina saccule otic vesicle muscle of thigh fetal liver hematopoietic progenitor cell lens otic placode cerebellar cortex skeletal muscle tissue triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding transferase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol nuclear membrane Biological process protein ubiquitination protein deubiquitination proteolysis involved in cellular protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63891 84585 Ensembl ENSG00000164068 ENSMUSG00000041528 UniProt Q5XPI4 Q5XPI3 RefSeq (mRNA) NM_022064 NM_032543 NM_001311152 RefSeq (protein) NP_071347 NP_001298081 NP_115932 Location (UCSC) Chr 3: 49.69 – 49.72 Mb Chr 9: 107.93 – 107.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.^[5] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).

See also

• RING finger domain