RNF125

E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.^[4]

RNF125
Identifiers
Aliases	RNF125, TRAC-1, TRAC1, TNORS, ring finger protein 125, E3 ubiquitin protein ligase, ring finger protein 125
External IDs	OMIM: 610432; MGI: 1914914; HomoloGene: 32369; GeneCards: RNF125; OMA:RNF125 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.1 Start 32,018,825 bp[1] End 32,073,219 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa oocyte secondary oocyte parietal pleura mucosa of sigmoid colon superficial temporal artery visceral pleura white blood cell monocyte inferior ganglion of vagus nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding p53 binding protein binding transferase activity zinc ion binding ubiquitin conjugating enzyme binding ubiquitin protein ligase activity Cellular component intracellular membrane-bounded organelle membrane Golgi membrane Golgi apparatus VCP-NPL4-UFD1 AAA ATPase complex Biological process adaptive immune response positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination immune system process ubiquitin-dependent protein catabolic process negative regulation of type I interferon production negative regulation of RIG-I signaling pathway protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54941 67664 Ensembl ENSG00000101695 ENSMUSG00000033107 UniProt Q96EQ8 Q9D9R0 RefSeq (mRNA) NM_017831 NM_026301 NM_001364973 RefSeq (protein) NP_060301 NP_080577 NP_001351902 Location (UCSC) Chr 18: 32.02 – 32.07 Mb n/a PubMed search [2] [3]
Wikidata
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This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.^[4]