RNF14

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.^[5][6][7]

RNF14
Identifiers
Aliases	RNF14, ARA54, HFB30, TRIAD2, HRIHFB2038, ring finger protein 14
External IDs	OMIM: 605675; MGI: 1929668; HomoloGene: 129170; GeneCards: RNF14; OMA:RNF14 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,958,328 bp[1] End 141,990,292 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 20.2 cM Start 38,417,590 bp[2] End 38,450,902 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell oocyte secondary oocyte right testis right adrenal cortex left testis Achilles tendon islet of Langerhans rectum left adrenal gland Top expressed in CA3 field perirhinal cortex entorhinal cortex dorsal tegmental nucleus central gray substance of midbrain superior colliculus subiculum ventral tegmental area inferior colliculi medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity transcription coactivator activity metal ion binding ubiquitin-protein transferase activity ubiquitin-like protein transferase activity protein binding androgen receptor binding ubiquitin conjugating enzyme binding transferase activity Cellular component cytoplasm ubiquitin ligase complex nucleus cytosol Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein polyubiquitination transcription, DNA-templated positive regulation of transcription, DNA-templated protein ubiquitination regulation of androgen receptor signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process signal transduction ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9604 56736 Ensembl ENSG00000013561 ENSMUSG00000060450 UniProt Q9UBS8 Q9JI90 RefSeq (mRNA) NM_001201365 NM_004290 NM_183398 NM_183399 NM_183400 NM_183401 NM_001164621 NM_001164622 NM_020012 NM_001361264 NM_001361265 NM_001361266 NM_001361267 NM_001361268 NM_001361269 RefSeq (protein) NP_001188294 NP_004281 NP_899645 NP_899646 NP_899647 NP_899648 NP_001158093 NP_001158094 NP_064396 NP_001348193 NP_001348194 NP_001348195 NP_001348196 NP_001348197 NP_001348198 Location (UCSC) Chr 5: 141.96 – 141.99 Mb Chr 18: 38.42 – 38.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.^[7] Another function of RNF14 protein relates to its regulation of the inter-relationship between bioenergetic status and inflammation. It influences the expression of mitochondrial and immune-related genes in skeletal muscle including cytokines and interferon regulatory factors.^[8]

Interactions

RNF14 has been shown to interact with the Androgen receptor.^{[5][9][10][11]}

See also

• RING finger domain