RNF167

Ring finger protein 167 is a protein that in humans is encoded by the RNF167 gene.^[5]

RNF167
Identifiers
Aliases	RNF167, 5730408C10Rik, RING105, LP2254, ring finger protein 167
External IDs	OMIM: 610431; MGI: 1917760; HomoloGene: 41046; GeneCards: RNF167; OMA:RNF167 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,940,008 bp[1] End 4,945,222 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 70,538,061 bp[2] End 70,542,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte apex of heart mucosa of transverse colon left testis right testis muscle layer of sigmoid colon right lobe of thyroid gland anterior pituitary skin of abdomen right hemisphere of cerebellum Top expressed in granulocyte thymus lactiferous gland lip spleen right lung mesenteric lymph nodes right lung lobe neural layer of retina duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding metal ion binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity Cellular component cytoplasm integral component of membrane membrane endomembrane system Biological process negative regulation of cell cycle protein polyubiquitination protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26001 70510 Ensembl ENSG00000108523 ENSMUSG00000040746 UniProt Q9H6Y7 Q91XF4 RefSeq (mRNA) NM_015528 NM_001320356 NM_001320357 NM_001320358 NM_001320359 NM_001320360 NM_001320361 NM_001320362 NM_001320363 NM_001320364 NM_001320365 NM_001370303 NM_001370304 NM_001370305 NM_001370306 NM_001370307 NM_001370308 NM_001370311 NM_001370313 NM_001375485 NM_027445 NM_001316728 NM_001363134 RefSeq (protein) NP_001307285 NP_001307286 NP_001307287 NP_001307288 NP_001307289 NP_001307290 NP_001307291 NP_001307292 NP_001307293 NP_001307294 NP_056343 NP_001357232 NP_001357233 NP_001357234 NP_001357235 NP_001357236 NP_001357237 NP_001357240 NP_001357242 NP_001362414 NP_001303657 NP_081721 NP_001350063 Location (UCSC) Chr 17: 4.94 – 4.95 Mb Chr 11: 70.54 – 70.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation.^[6]