RNF19A

E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.^[5][6][7]

RNF19A
Identifiers
Aliases	RNF19A, RNF19, ring finger protein 19A, RBR E3 ubiquitin protein ligase
External IDs	OMIM: 607119; MGI: 1353623; HomoloGene: 8501; GeneCards: RNF19A; OMA:RNF19A - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 100,257,060 bp[1] End 100,336,218 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 36,240,079 bp[2] End 36,283,293 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sperm epithelium of colon right lung canal of the cervix gallbladder epithelium of nasopharynx left uterine tube tonsil mucosa of paranasal sinus Top expressed in spermatid spermatocyte seminiferous tubule renal corpuscle granulocyte lumbar spinal ganglion medullary collecting duct fetal liver hematopoietic progenitor cell zygote secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding ubiquitin conjugating enzyme binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm integral component of membrane microtubule organizing center centrosome cytoskeleton membrane ubiquitin ligase complex cytosol hippocampal mossy fiber to CA3 synapse postsynapse glutamatergic synapse Biological process microtubule cytoskeleton organization positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination protein polyubiquitination regulation of protein catabolic process at postsynapse, modulating synaptic transmission ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25897 30945 Ensembl ENSG00000034677 ENSMUSG00000022280 UniProt Q9NV58 P50636 RefSeq (mRNA) NM_001280539 NM_015435 NM_183419 NM_001353837 NM_001353838 NM_013923 NM_001357631 RefSeq (protein) NP_001267468 NP_056250 NP_904355 NP_001340766 NP_001340767 NP_038951 NP_001344560 Location (UCSC) Chr 8: 100.26 – 100.34 Mb Chr 15: 36.24 – 36.28 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.^[7]

See also

• RING finger domain