RNF216

E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.^[5]

RNF216
Identifiers
Aliases	RNF216, CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN, ring finger protein 216
External IDs	OMIM: 609948; MGI: 1344349; HomoloGene: 19442; GeneCards: RNF216; OMA:RNF216 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 5,620,047 bp[1] End 5,781,696 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 142,976,648 bp[2] End 143,098,749 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis saphenous vein sperm stromal cell of endometrium oocyte granulocyte Achilles tendon secondary oocyte Top expressed in spermatid hand tail of embryo spermatocyte genital tubercle otic vesicle zygote granulocyte secondary oocyte morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding ubiquitin protein ligase activity transferase activity Cellular component cytoplasm nucleus nucleoplasm cytosol Schaffer collateral - CA1 synapse postsynaptic endocytic zone glutamatergic synapse Biological process protein K48-linked ubiquitination negative regulation of type I interferon production viral process regulation of interferon-beta production protein ubiquitination regulation of defense response to virus by host proteasome-mediated ubiquitin-dependent protein catabolic process apoptotic process protein catabolic process, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54476 108086 Ensembl ENSG00000011275 ENSMUSG00000045078 UniProt Q9NWF9 P58283 RefSeq (mRNA) NM_019011 NM_207111 NM_207116 NM_001377156 NM_080561 NM_207110 NM_001359851 RefSeq (protein) NP_996994 NP_996999 NP_001364085 NP_542128 NP_996993 NP_001346780 Location (UCSC) Chr 7: 5.62 – 5.78 Mb Chr 5: 142.98 – 143.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.^[5]

See also

• RING finger domain

Interactions

RNF216 has been shown to interact with TLR9^[6] and RIPK1.^[7]