RNF24

Ring finger protein 24 is a protein that in humans is encoded by the RNF24 gene.^[5][6]

RNF24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EP4
Identifiers
Aliases	RNF24, G1L, ring finger protein 24
External IDs	OMIM: 612489; MGI: 1261771; HomoloGene: 5223; GeneCards: RNF24; OMA:RNF24 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,927,309 bp[1] End 4,015,558 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.32 cM Start 131,139,984 bp[2] End 131,194,812 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte blood pericardium cartilage tissue nipple renal medulla stromal cell of endometrium trigeminal ganglion endothelial cell Descending thoracic aorta Top expressed in zygote secondary oocyte otolith organ utricle human kidney seminiferous tubule ganglionic eminence hand right kidney proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding ubiquitin protein ligase activity metal ion binding Cellular component integral component of membrane Golgi membrane membrane Golgi apparatus endomembrane system Biological process protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11237 51902 Ensembl ENSG00000101236 ENSMUSG00000048911 UniProt Q9Y225 Q8BGI1 RefSeq (mRNA) NM_001134337 NM_001134338 NM_007219 NM_001321749 NM_016502 NM_178607 RefSeq (protein) NP_001127809 NP_001127810 NP_001308678 NP_009150 NP_848722 Location (UCSC) Chr 20: 3.93 – 4.02 Mb Chr 2: 131.14 – 131.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RNF24 binds TRPC6 (603652) and other transient receptor potential cation channel (TRPC) family members and is involved in regulation of intracellular trafficking of TRPCs.^[6] In addition, RNF24 contains similarity to the Drosophila goliath protein and thus may function as a transcription factor.^[5]