RNF34

E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.^[5][6]

RNF34
Identifiers
Aliases	RNF34, CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
External IDs	OMIM: 608299; MGI: 2153340; HomoloGene: 11839; GeneCards: RNF34; OMA:RNF34 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 121,400,083 bp[1] End 121,430,623 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 122,988,111 bp[2] End 123,009,354 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii triceps brachii muscle glutes ganglionic eminence muscle of thigh gonad middle temporal gyrus Brodmann area 23 Top expressed in zygote secondary oocyte primary oocyte tail of embryo right ventricle medial ganglionic eminence genital tubercle spermatid granulocyte temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding phosphatidylinositol phosphate binding p53 binding ubiquitin protein ligase binding protein binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm endomembrane system nucleus membrane plasma membrane nuclear speck nucleoplasm cytosol nuclear body Biological process negative regulation of signal transduction by p53 class mediator negative regulation of extrinsic apoptotic signaling pathway via death domain receptors nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway protein K48-linked ubiquitination negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis apoptotic process regulation of oxygen metabolic process cellular response to cold protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80196 80751 Ensembl ENSG00000170633 ENSMUSG00000029474 UniProt Q969K3 Q99KR6 RefSeq (mRNA) NM_194271 NM_001256858 NM_025126 NM_001394208 NM_030564 RefSeq (protein) NP_001243787 NP_079402 NP_919247 NP_085041 Location (UCSC) Chr 12: 121.4 – 121.43 Mb Chr 5: 122.99 – 123.01 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6]