RNF38

RING finger protein 38 is a protein that in humans is encoded by the RNF38 gene.^[5]

RNF38
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4J, 4V3K, 4V3L
Identifiers
Aliases	RNF38, ring finger protein 38
External IDs	OMIM: 612488; MGI: 1920719; HomoloGene: 32550; GeneCards: RNF38; OMA:RNF38 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.2 Start 36,336,396 bp[1] End 36,487,548 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 44,126,210 bp[2] End 44,233,789 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte left testis right testis ganglionic eminence tail of epididymis metanephric glomerulus germinal epithelium Epithelium of choroid plexus Brodmann area 23 Top expressed in zygote secondary oocyte seminiferous tubule primary oocyte aortic valve ascending aorta genital tubercle tail of embryo blood ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding ubiquitin-protein transferase activity ubiquitin protein ligase activity transferase activity Cellular component sperm flagellum nucleus nucleoplasm Biological process male gonad development protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 152006 73469 Ensembl ENSG00000137075 ENSMUSG00000035696 UniProt Q9H0F5 Q8BI21 RefSeq (mRNA) NM_022781 NM_194328 NM_194329 NM_194330 NM_194331 NM_194332 NM_001038993 NM_175201 NM_001355181 NM_001379574 NM_001379575 NM_001379576 NM_001379577 NM_001379578 NM_001379579 NM_001379580 NM_001379581 RefSeq (protein) NP_073618 NP_919309 NP_919310 NP_919311 NP_919313 NP_001034082 NP_780410 NP_001342110 NP_001366503 NP_001366504 NP_001366505 NP_001366506 NP_001366507 NP_001366508 NP_001366509 NP_001366510 Location (UCSC) Chr 9: 36.34 – 36.49 Mb Chr 4: 44.13 – 44.23 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]

See also

• RING finger domain