RNF5

E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene.^[5][6]

RNF5
Identifiers
Aliases	RNF5, RING5, RMA1, ring finger protein 5
External IDs	OMIM: 602677; MGI: 1860076; HomoloGene: 56004; GeneCards: RNF5; OMA:RNF5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,178,405 bp[1] End 32,180,793 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.18 cM Start 34,820,065 bp[2] End 34,822,664 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence human kidney ventricular zone right adrenal gland mucosa of transverse colon right adrenal cortex monocyte apex of heart left ventricle duodenum Top expressed in proximal tubule right kidney neural tube neural layer of retina yolk sac ganglionic eminence human kidney Pons brown adipose tissue olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding ubiquitin-protein transferase activity protein binding ubiquitin-like protein conjugating enzyme binding transferase activity identical protein binding zinc ion binding ubiquitin protein ligase activity protein-containing complex binding Cellular component integral component of membrane mitochondrial membranes membrane mitochondrion Derlin-1 retrotranslocation complex endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum quality control compartment Biological process response to bacterium protein K63-linked ubiquitination ER-associated misfolded protein catabolic process regulation of autophagosome assembly protein K48-linked ubiquitination protein destabilization protein ubiquitination negative regulation of autophagy transmembrane transport endoplasmic reticulum mannose trimming ubiquitin-dependent ERAD pathway ERAD pathway ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6048 54197 Ensembl ENSG00000227277 ENSG00000223767 ENSG00000228907 ENSG00000183574 ENSG00000204308 ENSG00000225452 ENSG00000228405 ENSMUSG00000015478 UniProt Q99942 O35445 RefSeq (mRNA) NM_006913 NM_019403 RefSeq (protein) NP_008844 NP_062276 Location (UCSC) Chr 6: 32.18 – 32.18 Mb Chr 17: 34.82 – 34.82 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.^[6]