ROBO2

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.^[5][6]

ROBO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEM, 1UJT, 2EDJ
Identifiers
Aliases	ROBO2, SAX3, roundabout guidance receptor 2
External IDs	OMIM: 602431; MGI: 1890110; HomoloGene: 43188; GeneCards: ROBO2; OMA:ROBO2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p12.3 Start 75,906,695 bp[1] End 77,649,964 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.1 Start 73,688,727 bp[2] End 74,208,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone buccal mucosa cell prefrontal cortex islet of Langerhans cartilage tissue Brodmann area 46 Pons endothelial cell gonad Top expressed in Rostral migratory stream hand genital tubercle dentate gyrus of hippocampal formation granule cell superior frontal gyrus neural layer of retina ganglionic eminence primary visual cortex olfactory bulb superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding axon guidance receptor activity Cellular component integral component of membrane membrane cell surface axolemma extracellular exosome plasma membrane Biological process cell differentiation ureteric bud development kidney development negative regulation of synapse assembly Roundabout signaling pathway positive regulation of axonogenesis nervous system development multicellular organism development chemotaxis central nervous system development cellular response to hormone stimulus olfactory bulb interneuron development apoptotic process involved in luteolysis negative regulation of negative chemotaxis axon midline choice point recognition metanephros development homophilic cell adhesion via plasma membrane adhesion molecules retinal ganglion cell axon guidance brain development spinal cord development axon guidance outflow tract septum morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion formation positive regulation of Notch signaling pathway involved in heart induction aorta development ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6092 268902 Ensembl ENSG00000185008 ENSMUSG00000052516 UniProt Q9HCK4 Q7TPD3 RefSeq (mRNA) NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942 NM_001378190 NM_001378191 NM_001378192 NM_001378193 NM_001378194 NM_001378195 NM_001378196 NM_001378197 NM_001378198 NM_001378199 NM_001378200 NM_001378201 NM_001378202 NM_001378203 NM_001394212 NM_001394213 NM_001394214 NM_001395656 NM_001395657 NM_175549 NM_001358490 NM_001358491 NM_001358492 NM_001358493 NM_001358494 RefSeq (protein) NP_001122401 NP_001276968 NP_001276969 NP_001276994 NP_002933 NP_001365119 NP_001365120 NP_001365121 NP_001365122 NP_001365123 NP_001365124 NP_001365125 NP_001365126 NP_001365127 NP_001365128 NP_001365129 NP_001365130 NP_001365131 NP_001365132 n/a Location (UCSC) Chr 3: 75.91 – 77.65 Mb Chr 16: 73.69 – 74.21 Mb PubMed search [3] [4]
Wikidata
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