RPH3A

Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene.^[4][5][6] It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.^[7]

RPH3A
Identifiers
Aliases	RPH3A
External IDs	OMIM: 612159; MGI: 102788; HomoloGene: 7921; GeneCards: RPH3A; OMA:RPH3A - orthologs
Gene location (Mouse) Chr. Chromosome 5 (mouse)[1] Band 5|5 F Start 121,078,562 bp[1] End 121,148,155 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in primary visual cortex superior frontal gyrus cerebellar cortex dentate gyrus of hippocampal formation granule cell dorsal tegmental nucleus superior colliculus anterior horn of spinal cord central gray substance of midbrain medial vestibular nucleus zygote BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding phosphatidylinositol phosphate binding lipid binding clathrin binding syntaxin binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding zinc ion binding inositol 1,4,5 trisphosphate binding selenium binding phosphate ion binding calcium ion binding protein-containing complex binding Cellular component synapse cell junction membrane Golgi apparatus synaptic vesicle membrane secretory granule plasma membrane synaptic vesicle neuron projection extrinsic component of membrane cytosol protein-containing complex cytoplasmic vesicle cell projection dendritic spine postsynaptic membrane intracellular anatomical structure Biological process protein transport intracellular protein transport calcium ion-regulated exocytosis of neurotransmitter vesicle fusion regulation of calcium ion-dependent exocytosis spontaneous neurotransmitter secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22895 19894 Ensembl ENSG00000089169 ENSMUSG00000029608 UniProt Q9Y2J0 P47708 RefSeq (mRNA) NM_001143854 NM_014954 NM_011286 NM_001302344 NM_001302345 RefSeq (protein) NP_001137326 NP_055769 NP_001334881 NP_001334882 NP_001334883 NP_001334884 NP_001289273 NP_001289274 NP_035416 Location (UCSC) n/a Chr 5: 121.08 – 121.15 Mb PubMed search [2] [3]
Wikidata
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Interactions

RPH3A has been shown to interact with RAB3A,^[8][9][10] RAB3B^[8][10] and CASK.^[11]