60S ribosomal protein L14

60S ribosomal protein L14 is a protein that in humans is encoded by the RPL14 gene.^[5][6]

RPL14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AJ0, 4UG0, 4V6X
Identifiers
Aliases	RPL14, CAG-ISL-7, CTG-B33, L14, RL14, hRL14, ribosomal protein L14
External IDs	OMIM: 617414; MGI: 1914365; HomoloGene: 68375; GeneCards: RPL14; OMA:RPL14 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 40,457,292 bp[1] End 40,468,587 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 120,400,510 bp[2] End 120,403,720 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary body of pancreas right ovary ganglionic eminence skin of abdomen canal of the cervix gastric mucosa body of uterus muscle layer of sigmoid colon skin of leg Top expressed in blastocyst morula embryo embryo ventricular zone lip yolk sac dentate gyrus of hippocampal formation granule cell superior frontal gyrus muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cadherin binding RNA binding structural constituent of ribosome Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome postsynaptic density Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit biogenesis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9045 67115 Ensembl ENSG00000188846 ENSMUSG00000025794 UniProt P50914 Q9CR57 RefSeq (mRNA) NM_003973 NM_001034996 NM_025974 RefSeq (protein) NP_001030168 NP_003964 NP_080250 Location (UCSC) Chr 3: 40.46 – 40.47 Mb Chr 9: 120.4 – 120.4 Mb PubMed search [3] [4]
Wikidata
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Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

Interactions

RPL14 has been shown to interact with PHLDA1.^[7]