PHLDA1

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.^[5][6][7]

PHLDA1
Identifiers
Aliases	PHLDA1, DT1P1B11, PHRIP, TDAG51, pleckstrin homology like domain family A member 1
External IDs	OMIM: 605335; MGI: 1096880; HomoloGene: 7203; GeneCards: PHLDA1; OMA:PHLDA1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.2 Start 76,025,447 bp[1] End 76,031,776 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 111,342,147 bp[2] End 111,344,506 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone stromal cell of endometrium ganglionic eminence salivary gland minor salivary glands gallbladder vagina right lung tibial nerve upper lobe of left lung Top expressed in parotid gland submandibular gland lacrimal gland left lobe of liver otic placode lactiferous gland crypt of lieberkuhn of small intestine epithelium of stomach granulocyte stria vascularis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm cytoplasmic vesicle cytosol nucleus nucleolus Biological process apoptotic process FasL biosynthetic process G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22822 21664 Ensembl ENSG00000139289 ENSMUSG00000020205 UniProt Q8WV24 Q62392 RefSeq (mRNA) NM_007350 NM_009344 RefSeq (protein) NP_031376 NP_033370 Location (UCSC) Chr 12: 76.03 – 76.03 Mb Chr 10: 111.34 – 111.34 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.^[7]

Interactions

PHLDA1 has been shown to interact with RPL14,^[8] EIF3D^[8] and PABPC4.^[8]