RPL22L1

Ribosomal protein L22 like 1 (RPL22L1), or eL22L1, is a protein that in humans is encoded by the RPL22L1 gene. ^[5]

RPL22L1
Identifiers
Aliases	RPL22L1, ribosomal protein L22 like 1
External IDs	MGI: 1915278; HomoloGene: 134069; GeneCards: RPL22L1; OMA:RPL22L1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 170,864,875 bp[1] End 170,870,208 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 28,859,585 bp[2] End 28,861,573 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue body of pancreas skin of arm appendix gums gingival epithelium ventricular zone lymph node spleen skin of abdomen Top expressed in embryo epiblast embryo ventricular zone lens uterus pancreas Hypothalamus ileum ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component cytosolic large ribosomal subunit ribosome intracellular anatomical structure Biological process cytoplasmic translation protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200916 68028 Ensembl ENSG00000163584 ENSMUSG00000039221 UniProt Q6P5R6 Q9D7S7 RefSeq (mRNA) NM_001099645 NM_001320451 NM_026517 NM_001347226 RefSeq (protein) NP_001093115 NP_001307380 NP_001334155 NP_080793 Location (UCSC) Chr 3: 170.86 – 170.87 Mb Chr 3: 28.86 – 28.86 Mb PubMed search [3] [4]
Wikidata
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Function

eL22L1 is a ribosomal protein paralog of the eL22 protein of the 60S ribosomal subunit. This paralog is divergent from the normal copy, and is expressed when the normal copy is deleted from mice.^[6] This compensation implies a ribosome function similar to the normal copy, though eL22L1 has also been implicates in other extraribosomal roles including pre-mRNA splicing regulation in zebrafish.^[7]

See also

• RPL22
• 60S ribosomal subunit