60S ribosomal protein L23

Large ribosomal subunit protein uL14 is a protein that in humans is encoded by the RPL23 gene.^[5][6]

RPL23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7R, 4V5Z, 4V6X, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 5AJ0, 3J7Q, 4UG0, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL23, L23, rpL17, ribosomal protein L23
External IDs	OMIM: 603662; MGI: 1929455; HomoloGene: 68103; GeneCards: RPL23; OMA:RPL23 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,847,860 bp[1] End 38,853,764 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.1 cM Start 97,668,353 bp[2] End 97,673,263 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left ovary right ovary ventricular zone right uterine tube monocyte canal of the cervix body of uterus right lung left adrenal cortex Top expressed in yolk sac embryo embryo ventricular zone lip morula blastocyst neural layer of retina muscle of thigh dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome large ribosomal subunit rRNA binding protein binding RNA binding transcription coactivator binding ubiquitin protein ligase binding ubiquitin ligase inhibitor activity Cellular component cytosol ribosome membrane focal adhesion extracellular exosome cytosolic large ribosomal subunit extracellular matrix nucleoplasm cytoplasm nucleolus postsynaptic density protein-containing complex Biological process ribosomal protein import into nucleus viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing negative regulation of transcription by RNA polymerase II positive regulation of cell population proliferation positive regulation of gene expression protein-DNA complex disassembly positive regulation of transcription by RNA polymerase II protein stabilization cellular response to actinomycin D positive regulation of signal transduction by p53 class mediator negative regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9349 65019 Ensembl ENSG00000125691 ENSMUSG00000071415 UniProt P62829 P62830 RefSeq (mRNA) NM_000978 NM_022891 RefSeq (protein) NP_000969 NP_075029 Location (UCSC) Chr 17: 38.85 – 38.85 Mb Chr 11: 97.67 – 97.67 Mb PubMed search [3] [4]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the universal ribosomal protein uL14 family. It is located in the cytoplasm. This gene has been referred to as RPL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]