40S ribosomal protein S29

40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29 gene.^[5][6][7]

RPS29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 4D61, 5FLX, 4KZX, 4D5L, 4V5Z, 4UJD, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS29, DBA13, S29, ribosomal protein S29, uS14
External IDs	OMIM: 603633; MGI: 107681; HomoloGene: 83197; GeneCards: RPS29; OMA:RPS29 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.3 Start 49,570,984 bp[1] End 49,599,164 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,204,496 bp[2] End 69,205,960 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caput epididymis human penis parietal pleura mucosa of sigmoid colon superficial temporal artery granulocyte nipple ganglionic eminence corpus epididymis mucosa of transverse colon Top expressed in embryo epiblast uterus yolk sac embryo blastocyst neural tube ganglionic eminence ventricular zone stomach More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome zinc ion binding metal ion binding Cellular component cytosol ribosome focal adhesion intracellular anatomical structure cytosolic small ribosomal subunit small ribosomal subunit extracellular exosome nucleoplasm cytoplasm endoplasmic reticulum rough endoplasmic reticulum polysomal ribosome cytoplasmic side of rough endoplasmic reticulum membrane Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6235 20090 Ensembl ENSG00000213741 ENSMUSG00000034892 UniProt P62273 P62274 RefSeq (mRNA) NM_001032 NM_001030001 NM_001351375 NM_009093 RefSeq (protein) NP_001023 NP_001025172 NP_001338304 NP_033119 Location (UCSC) Chr 14: 49.57 – 49.6 Mb Chr 12: 69.2 – 69.21 Mb PubMed search [3] [4]
Wikidata
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Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Clinical significance

Mutations in RPS29 cause Diamond–Blackfan anemia.^[8]