RPS6KA6

Ribosomal protein S6 kinase, 90kDa, polypeptide 6 is a protein in humans that is encoded by the RPS6KA6 gene. ^[4]

RPS6KA6
Identifiers
Aliases	RPS6KA6, PP90RSK4, RSK4, ribosomal protein S6 kinase A6, RSK-4, p90RSK6, S6K-alpha-6
External IDs	OMIM: 300303; MGI: 1914321; HomoloGene: 22816; GeneCards: RPS6KA6; OMA:RPS6KA6 - orthologs
Gene location (Mouse) Chr. X chromosome (mouse)[1] Band X|X E1 Start 110,297,889 bp[1] End 110,447,656 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibia islet of Langerhans ganglionic eminence middle temporal gyrus pituitary gland popliteal artery anterior pituitary thyroid gland seminal vesicula Top expressed in tail of embryo genital tubercle yolk sac ventricular zone primitive streak zygote secondary oocyte spermatid epiblast embryo More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding metal ion binding ATP binding magnesium ion binding protein serine/threonine kinase activity kinase activity protein kinase activity ribosomal protein S6 kinase activity Cellular component cytoplasm nucleolus mitochondrion nucleus cytosol fibrillar center nucleoplasm Biological process intracellular signal transduction phosphorylation protein phosphorylation negative regulation of embryonic development central nervous system development negative regulation of mesoderm development negative regulation of ERK1 and ERK2 cascade signal transduction DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27330 67071 Ensembl n/a ENSMUSG00000025665 UniProt Q9UK32 Q7TPS0 RefSeq (mRNA) NM_014496 NM_001330512 NM_025949 NM_001374707 NM_001398774 RefSeq (protein) NP_001317441 NP_055311 NP_080225 NP_001361636 NP_001385703 Location (UCSC) n/a Chr X: 110.3 – 110.45 Mb PubMed search [2] [3]
Wikidata
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This gene encodes a member of ribosomal S6 kinase family, serine-threonin protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010].