RRM1

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.^[5][6]

RRM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WGH, 3HNC, 3HND, 3HNE, 3HNF, 5D1Y, 4X3V
Identifiers
Aliases	RRM1, R1, RIR1, RR1, ribonucleotide reductase catalytic subunit M1
External IDs	OMIM: 180410; MGI: 98180; HomoloGene: 806; GeneCards: RRM1; OMA:RRM1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 4,094,707 bp[1] End 4,138,932 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 54.72 cM Start 102,090,902 bp[2] End 102,118,978 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence human penis nipple trabecular bone skin of hip skin of thigh mucosa of pharynx vulva Achilles tendon Top expressed in fetal liver hematopoietic progenitor cell maxillary prominence gastrula mandibular prominence ventricular zone primitive streak spermatocyte tibiofemoral joint endothelial cell of lymphatic vessel decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding catalytic activity oxidoreductase activity ATP binding protein binding ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor identical protein binding purine nucleotide binding disordered domain specific binding Cellular component cytoplasm cytosol nuclear envelope ribonucleoside-diphosphate reductase complex cell projection soma Biological process DNA replication metabolism mitotic cell cycle pyrimidine nucleobase metabolic process male gonad development deoxyribonucleotide biosynthetic process response to ionizing radiation cell proliferation in forebrain protein complex oligomerization protein heterotetramerization retina development in camera-type eye nucleobase-containing small molecule interconversion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6240 20133 Ensembl ENSG00000167325 ENSMUSG00000030978 UniProt P23921 P07742 RefSeq (mRNA) NM_001033 NM_001318064 NM_001318065 NM_001330193 NM_009103 RefSeq (protein) NP_001024 NP_001304993 NP_001304994 NP_001317122 NP_033129 Location (UCSC) Chr 11: 4.09 – 4.14 Mb Chr 7: 102.09 – 102.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

• Ribonucleotide reductase