RRM2

Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene.^[5][6]

RRM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UW2, 3OLJ, 3VPM, 3VPN, 3VPO
Identifiers
Aliases	RRM2, R2, RR2, RR2M, ribonucleotide reductase regulatory subunit M2
External IDs	OMIM: 180390; MGI: 98181; HomoloGene: 20277; GeneCards: RRM2; OMA:RRM2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 10,120,698 bp[1] End 10,211,725 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.3|12 8.5 cM Start 24,758,240 bp[2] End 24,764,145 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone ganglionic eminence trabecular bone thymus bone marrow bone marrow cells amniotic fluid gingival epithelium appendix Top expressed in gastrula decidua fetal liver hematopoietic progenitor cell somite primitive streak medial ganglionic eminence tibiofemoral joint abdominal wall renal corpuscle endothelial cell of lymphatic vessel More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding oxidoreductase activity ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ferric iron binding protein homodimerization activity Cellular component cytoplasm cytosol ribonucleoside-diphosphate reductase complex Biological process regulation of transcription involved in G1/S transition of mitotic cell cycle deoxyribonucleotide biosynthetic process DNA replication negative regulation of G0 to G1 transition deoxyribonucleotide metabolic process protein complex oligomerization protein heterotetramerization nucleobase-containing small molecule interconversion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6241 20135 Ensembl ENSG00000171848 ENSMUSG00000020649 UniProt P31350 P11157 RefSeq (mRNA) NM_001165931 NM_001034 NM_009104 RefSeq (protein) NP_001025 NP_001159403 NP_033130 Location (UCSC) Chr 2: 10.12 – 10.21 Mb Chr 12: 24.76 – 24.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini.^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".