RRN3

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene.^[5][6][7]

RRN3
Identifiers
Aliases	RRN3, A-270G1.2, TIFIA, RRN3 homolog, RNA polymerase I transcription factor
External IDs	OMIM: 605121; MGI: 1925255; HomoloGene: 39531; GeneCards: RRN3; OMA:RRN3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.11 Start 15,060,033 bp[1] End 15,094,311 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 13,598,572 bp[2] End 13,632,703 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence gastrocnemius muscle ventricular zone endometrium islet of Langerhans rectum subcutaneous adipose tissue ovary muscle of thigh Top expressed in cumulus cell neural tube cardiac muscle tissue of left ventricle epiblast spermatocyte morula morula ventricular zone muscle of thigh ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase binding RNA polymerase I core promoter sequence-specific DNA binding RNA polymerase I core binding RNA polymerase I general transcription initiation factor activity Cellular component nucleolus nucleoplasm nucleus Biological process in utero embryonic development nucleolus organization positive regulation of neuron projection development regulation of transcription, DNA-templated cell population proliferation negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator DNA-templated transcription, initiation regulation of DNA-templated transcription, initiation positive regulation of transcription, DNA-templated cytoplasm organization transcription, DNA-templated homeostasis of number of cells transcription initiation from RNA polymerase I promoter ribosome biogenesis regulation of transcription by RNA polymerase I RNA polymerase I preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54700 106298 Ensembl ENSG00000085721 ENSG00000278494 ENSMUSG00000022682 UniProt Q9NYV6 B2RS91 RefSeq (mRNA) NM_001301064 NM_018427 NM_001039521 RefSeq (protein) NP_001287993 NP_060897 NP_001034610 Location (UCSC) Chr 16: 15.06 – 15.09 Mb Chr 16: 13.6 – 13.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RRN3 has been shown to interact with TAF1B.^[6]