RTFDC1

Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene.^[5]

RTF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZE, 2DB9, 3U1U, 4L1P, 4L1U
Identifiers
Aliases	15890 RTF1, RTF2, GTL7, KIAA0252, RTF1 homolog, Paf1/RNA polymerase II complex component, RTF2, C20orf43, CDAO5, HSPC164, SHUJUN-3, replication termination factor 2 domain containing 1, replication termination factor 2, RTFDC1
External IDs	OMIM: 611633; MGI: 1309480; HomoloGene: 133868 9501; GeneCards: RTF2 RTF1, RTF2; OMA:RTF1, RTF2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1, 20q13.31 Start 41,408,408 bp[1] End 41,483,563 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,675,068 bp[2] End 119,735,407 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Skeletal muscle tissue of rectus abdominis palpebral conjunctiva epithelium of colon ventricular zone bone marrow cell cerebellar hemisphere Skeletal muscle tissue of biceps brachii body of tongue monocyte Top expressed in tail of embryo zygote genital tubercle hand yolk sac superior cervical ganglion foot interventricular septum primitive streak fossa More reference expression data BioGPS 51507/ More reference expression data
Gene ontology Molecular function protein binding single-stranded DNA binding DNA binding RNA polymerase II C-terminal domain phosphoserine binding RNA binding molecular function Cellular component nucleolus nucleus Cdc73/Paf1 complex nucleoplasm cellular component replication fork chromosome Biological process blastocyst growth histone modification regulation of transcription, DNA-templated positive regulation of transcription elongation from RNA polymerase II promoter histone H3-K4 trimethylation positive regulation of histone H3-K4 methylation transcription, DNA-templated Wnt signaling pathway positive regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II stem cell population maintenance endodermal cell fate commitment transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter protein ubiquitination mitotic DNA replication termination site-specific DNA replication termination at RTS1 barrier biological process cellular response to hydroxyurea regulation of DNA stability Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23168,51507 23168,51507 76246 Ensembl ENSG00000137815 ENSG00000022277 ENSMUSG00000027304 UniProt Q92541 Q9BY42 A2AQ19 RefSeq (mRNA) NM_015138 NM_001283035 NM_001283036 NM_001283037 NM_016407 NM_030112 RefSeq (protein) NP_055953 NP_001269964 NP_001269965 NP_001269966 NP_057491 NP_084388 Location (UCSC) Chr 15: 41.41 – 41.48 Mb Chr 2: 119.68 – 119.74 Mb PubMed search [3] [4]
Wikidata
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