RTKN

Rhotekin is a protein that in humans is encoded by the RTKN gene.^[5][6][7]

RTKN
Identifiers
Aliases	RTKN, rhotekin
External IDs	OMIM: 602288; MGI: 107371; HomoloGene: 7522; GeneCards: RTKN; OMA:RTKN - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,425,835 bp[1] End 74,442,422 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3|6 35.94 cM Start 83,112,444 bp[2] End 83,129,560 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right lobe of liver tibial nerve sural nerve human kidney substantia nigra body of pancreas inferior ganglion of vagus nerve corpus callosum mucosa of transverse colon Top expressed in superior frontal gyrus lip primary visual cortex dentate gyrus of hippocampal formation granule cell internal carotid artery external carotid artery pontine nuclei right kidney lacrimal gland deep cerebellar nuclei More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase inhibitor activity protein binding Cellular component cytosol cellular component actomyosin contractile ring Biological process signal transduction apoptotic process negative regulation of GTPase activity regulation of apoptotic process Rho protein signal transduction septin cytoskeleton organization mitotic cytokinesis actomyosin contractile ring assembly cortical cytoskeleton organization septin ring organization protein localization to mitotic actomyosin contractile ring Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6242 20166 Ensembl ENSG00000114993 ENSMUSG00000034930 UniProt Q9BST9 Q8C6B2 RefSeq (mRNA) NM_001015055 NM_001015056 NM_033046 NM_001136227 NM_009106 NM_133641 NM_001355524 NM_001355525 RefSeq (protein) NP_001015055 NP_001015056 NP_149035 NP_001129699 NP_033132 NP_598396 NP_001342453 NP_001342454 Location (UCSC) Chr 2: 74.43 – 74.44 Mb Chr 6: 83.11 – 83.13 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.^[7]