RTN1

Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the RTN1 gene.^[5][6]

RTN1
Identifiers
Aliases	RTN1, NSP, reticulon 1
External IDs	OMIM: 600865; MGI: 1933947; HomoloGene: 49654; GeneCards: RTN1; OMA:RTN1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.1 Start 59,595,976 bp[1] End 59,870,776 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 72,258,526 bp[2] End 72,455,828 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell pons orbitofrontal cortex cerebellar vermis middle temporal gyrus superior frontal gyrus occipital lobe pars compacta parietal lobe Top expressed in dentate gyrus of hippocampal formation granule cell perirhinal cortex entorhinal cortex CA3 field superior frontal gyrus central gray substance of midbrain subiculum nucleus of stria terminalis primary visual cortex cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Golgi membrane Golgi apparatus Biological process neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6252 104001 Ensembl ENSG00000139970 ENSMUSG00000021087 UniProt Q16799 Q8K0T0 RefSeq (mRNA) NM_001243115 NM_021136 NM_206852 NM_206857 NM_001363702 NM_001007596 NM_001286448 NM_153457 RefSeq (protein) NP_066959 NP_996734 NP_001350631 NP_001007597 NP_001273377 NP_703187 Location (UCSC) Chr 14: 59.6 – 59.87 Mb Chr 12: 72.26 – 72.46 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.^[6]

Interactions

RTN1 has been shown to interact with BCL2-like 1^[7] and UGCG.^[8]