RTN2

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.^[5][6][7]

RTN2
Identifiers
Aliases	RTN2, NSP2, NSPL1, NSPLI, SPG12, reticulon 2
External IDs	OMIM: 603183; MGI: 107612; HomoloGene: 32180; GeneCards: RTN2; OMA:RTN2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,485,294 bp[1] End 45,497,055 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.54 cM Start 19,016,549 bp[2] End 19,030,085 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis muscle of thigh gastrocnemius muscle vastus lateralis muscle thoracic diaphragm triceps brachii muscle biceps brachii glutes body of tongue Skeletal muscle tissue of biceps brachii Top expressed in triceps brachii muscle muscle of thigh temporal muscle sternocleidomastoid muscle ankle digastric muscle extensor digitorum longus muscle vastus lateralis muscle medial head of gastrocnemius muscle tibialis anterior muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane T-tubule integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane terminal cisterna Biological process intracellular protein transmembrane transport regulation of glucose import Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6253 20167 Ensembl ENSG00000125744 ENSMUSG00000030401 UniProt O75298 Q96CG9 O70622 RefSeq (mRNA) NM_206902 NM_005619 NM_206900 NM_206901 NM_001025364 NM_013648 RefSeq (protein) NP_005610 NP_996783 NP_996784 NP_001020535 NP_038676 Location (UCSC) Chr 19: 45.49 – 45.5 Mb Chr 7: 19.02 – 19.03 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]