RUFY1

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene.^[5][6] It is named after the RUN and FYVE domains it contains.

RUFY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YQM, 2YW8
Identifiers
Aliases	RUFY1, RABIP4, ZFYVE12, RUN and FYVE domain containing 1
External IDs	OMIM: 610327; MGI: 2429762; HomoloGene: 23522; GeneCards: RUFY1; OMA:RUFY1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 179,550,554 bp[1] End 179,610,012 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 50,280,113 bp[2] End 50,321,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon sural nerve corpus callosum ventricular zone blood right uterine tube gastric mucosa granulocyte skin of leg Top expressed in primary oocyte neural layer of retina right kidney granulocyte muscle of thigh zygote transitional epithelium of urinary bladder proximal tubule retinal pigment epithelium secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding lipid binding SH3 domain binding SH2 domain binding Cellular component intracellular membrane-bounded organelle membrane cytoplasm cytosol nuclear speck early endosome membrane endosome nucleus Biological process protein transport endocytosis phosphatidylinositol biosynthetic process regulation of endocytosis small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80230 216724 Ensembl ENSG00000284260 ENSG00000176783 ENSMUSG00000020375 UniProt Q96T51 Q8BIJ7 RefSeq (mRNA) NM_001040451 NM_001040452 NM_025158 NM_172557 RefSeq (protein) NP_001035541 NP_001035542 NP_079434 NP_766145 Location (UCSC) Chr 5: 179.55 – 179.61 Mb Chr 11: 50.28 – 50.32 Mb PubMed search [3] [4]
Wikidata
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Interactions

RUFY1 has been shown to interact with BMX.^[5]