Relaxin/insulin-like family peptide receptor 1

Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors.^[5] It is a rhodopsin-like GPCR which is unusual in this class as it contains a large extracellular binding and signalling domain.^[6] Some reports suggest that RXFP1 forms homodimers,^[7][8] however the most recent evidence indicates that relaxin binds a non-homodimer of RXFP1.^[9][10]

RXFP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JM4, 2M7P
Identifiers
Aliases	RXFP1, LGR7, RXFPR1, Relaxin/insulin-like family peptide receptor 1, relaxin/insulin like family peptide receptor 1, relaxin family peptide receptor 1
External IDs	OMIM: 606654; MGI: 2682211; HomoloGene: 11007; GeneCards: RXFP1; OMA:RXFP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 158,315,311 bp[1] End 158,653,372 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 79,548,918 bp[2] End 79,645,187 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua endothelial cell endometrium Brodmann area 46 testicle prefrontal cortex Brodmann area 9 superior frontal gyrus Brodmann area 23 cingulate gyrus Top expressed in uterus genital tubercle primary visual cortex superior frontal gyrus cervix dentate gyrus of hippocampal formation granule cell atrioventricular valve muscle of thigh hippocampus proper cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity protein binding signal transducer activity metal ion binding G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure integral component of plasma membrane Biological process signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway activation of adenylate cyclase activity hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59350 381489 Ensembl ENSG00000171509 ENSMUSG00000034009 UniProt Q9HBX9 Q6R6I7 RefSeq (mRNA) NM_001253727 NM_001253728 NM_001253729 NM_001253730 NM_001253732 NM_001253733 NM_021634 NM_001363776 NM_212452 RefSeq (protein) NP_001240656 NP_001240657 NP_001240658 NP_001240659 NP_001240661 NP_001240662 NP_067647 NP_001350705 NP_997617 Location (UCSC) Chr 4: 158.32 – 158.65 Mb Chr 3: 79.55 – 79.65 Mb PubMed search [3] [4]
Wikidata
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See also

• Relaxin family peptide hormones
• Insulin/IGF/Relaxin family
• Relaxin
  • Relaxin-3