Relaxin/insulin-like family peptide receptor 4

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.^[5]

RXFP4
Identifiers
Aliases	RXFP4, GPCR142, GPR100, RLN3R2, RXFPR4, Relaxin/insulin-like family peptide receptor 4, relaxin/insulin like family peptide receptor 4, relaxin family peptide/INSL5 receptor 4
External IDs	OMIM: 609043; MGI: 2182926; HomoloGene: 18775; GeneCards: RXFP4; OMA:RXFP4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,941,638 bp[1] End 155,943,087 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,559,205 bp[2] End 88,560,449 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon sural nerve rectum granulocyte duodenum monocyte bone marrow blood appendix gastric mucosa Top expressed in embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding G protein-coupled receptor activity signal transducer activity galanin receptor activity G protein-coupled peptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of feeding behavior signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 339403 242093 Ensembl ENSG00000173080 ENSMUSG00000049741 UniProt Q8TDU9 Q7TQP4 RefSeq (mRNA) NM_181885 NM_181817 RefSeq (protein) NP_871001 NP_861538 Location (UCSC) Chr 1: 155.94 – 155.94 Mb Chr 3: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
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Function

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM]^[5]

See also

• Relaxin receptor