Radixin

Radixin is a protein that in humans is encoded by the RDX gene.^[5][6][7]

RDX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GC6, 1GC7, 1J19, 2D10, 2D11, 2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY
Identifiers
Aliases	RDX, DFNB24, radixin
External IDs	OMIM: 179410; MGI: 97887; HomoloGene: 37707; GeneCards: RDX; OMA:RDX - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.3 Start 109,864,295 bp[1] End 110,296,712 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 51,958,473 bp[2] End 52,011,763 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex visceral pleura parietal pleura left adrenal gland left adrenal cortex ventricular zone corpus callosum secondary oocyte tibia Achilles tendon Top expressed in primary oocyte secondary oocyte Gonadal ridge cumulus cell zygote dermis atrium lacrimal gland abdominal wall pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein domain specific binding ATPase binding protein kinase A binding cytoskeletal protein binding protein binding actin binding RNA binding cadherin binding Cellular component cytoplasm membrane focal adhesion filopodium ruffle myelin sheath plasma membrane apical part of cell stereocilium microvillus apical plasma membrane cortical actin cytoskeleton cleavage furrow extracellular exosome cytoskeleton cell periphery lamellipodium midbody T-tubule cell tip extracellular space cell projection Biological process regulation of cell size establishment of endothelial barrier microvillus assembly regulation of organelle assembly establishment of protein localization positive regulation of cell migration regulation of GTPase activity positive regulation of G1/S transition of mitotic cell cycle negative regulation of homotypic cell-cell adhesion regulation of actin filament bundle assembly positive regulation of gene expression negative regulation of GTPase activity negative regulation of adherens junction organization apical protein localization actin filament capping cellular response to thyroid hormone stimulus regulation of cell shape protein kinase A signaling regulation of ruffle assembly positive regulation of protein localization to early endosome positive regulation of early endosome to late endosome transport negative regulation of cell size regulation of Rap protein signal transduction cellular response to platelet-derived growth factor stimulus barbed-end actin filament capping protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5962 19684 Ensembl ENSG00000137710 ENSMUSG00000032050 UniProt P35241 P26043 RefSeq (mRNA) NM_002906 NM_001260492 NM_001260493 NM_001260494 NM_001260495 NM_001260496 NM_001104616 NM_001104617 NM_009041 RefSeq (protein) NP_001247421 NP_001247422 NP_001247423 NP_001247424 NP_001247425 NP_002897 NP_001098086 NP_001098087 NP_033067 Location (UCSC) Chr 11: 109.86 – 110.3 Mb Chr 9: 51.96 – 52.01 Mb PubMed search [3] [4]
Wikidata
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Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.^[7]

Interactions

Radixin has been shown to interact with GNA13.^[8]

See also

• ERM protein family