Regulatory region of repBA gene

In plasmids, the regulatory region of repBA gene forms a pseudoknot. The repA gene, which encodes a protein likely to function as an initiator for replication, and the repB gene are translationally coupled. The leader sequence of the repA mRNA contains two complementary sequences of 8 bases. Base-pairing between these two sequences forms a pseudoknot which is essential for translation. The first of these complementary sequences is found within a stem-loop, which forms a target for RNAI. Binding of RNAI to this stem-loop inhibits pseudoknot formation and translation of RepA.^[1][2]

Pseudoknot of the regulatory region of the repBA gene
Secondary structure of the pseudoknot of the regulatory region of the repBA gene
Identifiers
Rfam	RF01089
Other data
RNA type	Cis-reg
Domain(s)	Eukaryotes Prokaryotes
PDB structures	PDBe