Retinoid X receptor beta

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.^[5][6]

RXRB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H9U, 1UHL, 5HJP, 5I4V
Identifiers
Aliases	RXRB, DAUDI6, H-2RIIBP, NR2B2, RCoR-1, Retinoid X receptor beta, RXRbeta, RXR-beta
External IDs	OMIM: 180246; MGI: 98215; HomoloGene: 7923; GeneCards: RXRB; OMA:RXRB - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 33,193,588 bp[1] End 33,200,665 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,250,786 bp[2] End 34,257,373 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland granulocyte gastric mucosa left lobe of thyroid gland right coronary artery right uterine tube body of uterus right ovary pituitary gland canal of the cervix Top expressed in Ileal epithelium internal carotid artery external carotid artery granulocyte renal corpuscle muscle of thigh ankle crypt of lieberkuhn of small intestine motor neuron fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription coactivator activity zinc ion binding metal ion binding steroid hormone receptor activity nuclear receptor activity protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated retinoic acid receptor signaling pathway transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6257 20182 Ensembl ENSG00000235712 ENSG00000231321 ENSG00000227322 ENSG00000204231 ENSG00000206289 ENSG00000228333 ENSMUSG00000039656 UniProt P28702 Q5STP9 P28704 RefSeq (mRNA) NM_001270401 NM_001291989 NM_021976 NM_001205214 NM_001205215 NM_001205216 NM_011306 RefSeq (protein) NP_001257330 NP_001278918 NP_068811 NP_068811.1 NP_001192143 NP_001192144 NP_001192145 NP_035436 Location (UCSC) Chr 6: 33.19 – 33.2 Mb Chr 17: 34.25 – 34.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|alt=Vitamin D Synthesis Pathway (view / edit)]]

Vitamin D Synthesis Pathway (view / edit)

1. The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

See also

• Retinoid X receptor