RHOB

This article is about the ras homolog gene family. For the Rayburn House Office Building, see Rayburn House Office Building.

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.^[5][6]

RHOB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FV8
Identifiers
Aliases	RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6, ras homolog family member B
External IDs	OMIM: 165370; MGI: 107949; HomoloGene: 68377; GeneCards: RHOB; OMA:RHOB - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.1 Start 20,447,074 bp[1] End 20,449,440 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 8,547,661 bp[2] End 8,550,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa saphenous vein popliteal artery tibial arteries vena cava urethra internal globus pallidus nipple left uterine tube tail of epididymis Top expressed in molar decidua granulocyte dorsomedial hypothalamic nucleus left lung lobe olfactory tubercle globus pallidus lateral geniculate nucleus stroma of bone marrow subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding protein binding GTPase activity protein kinase binding Cellular component cytosol endosome late endosome membrane late endosome membrane focal adhesion plasma membrane early endosome cleavage furrow endosome membrane extracellular exosome nucleus intracellular anatomical structure cytoplasm cell cortex cell division site intracellular membrane-bounded organelle Biological process cell differentiation regulation of cell migration endosome to lysosome transport endothelial tube morphogenesis negative regulation of cell cycle positive regulation of angiogenesis positive regulation of endothelial cell migration multicellular organism development platelet activation cell adhesion negative regulation of cell migration angiogenesis Rho protein signal transduction cellular response to ionizing radiation protein transport intracellular protein transport regulation of small GTPase mediated signal transduction cellular response to hydrogen peroxide apoptotic process small GTPase mediated signal transduction positive regulation of apoptotic process transport mitotic cytokinesis G protein-coupled receptor signaling pathway actin filament organization regulation of cell shape cell migration establishment or maintenance of actin cytoskeleton polarity regulation of actin cytoskeleton organization actin filament bundle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388 11852 Ensembl ENSG00000143878 ENSMUSG00000054364 UniProt P62745 P62746 RefSeq (mRNA) NM_004040 NM_007483 RefSeq (protein) NP_004031 NP_031509 Location (UCSC) Chr 2: 20.45 – 20.45 Mb Chr 12: 8.55 – 8.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RHOB is a member of the Rho GTP-binding protein family.^[7]

Interactions

RHOB has been shown to interact with CIT,^[8] ARHGEF3,^[9] ARHGDIG^[10] and RHPN2.^[11]

See also

• neural crest