RIT1

GTP-binding protein Rit1 is a protein that in humans is encoded by the RIT1 gene.^[5][6][7]

RIT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KLZ
Identifiers
Aliases	RIT1, NS8, RIBB, RIT, ROC1, Ras like without CAAX 1
External IDs	OMIM: 609591; MGI: 108053; HomoloGene: 56003; GeneCards: RIT1; OMA:RIT1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,897,808 bp[1] End 155,911,404 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,624,145 bp[2] End 88,638,356 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte amniotic fluid Achilles tendon stromal cell of endometrium islet of Langerhans blood ventricular zone vagina palpebral conjunctiva granulocyte Top expressed in granulocyte saccule stroma of bone marrow seminal vesicula lip ectoderm otic vesicle esophagus lacrimal gland otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding calmodulin binding GTP binding GTPase activity GDP binding Cellular component membrane plasma membrane intracellular anatomical structure Biological process Ras protein signal transduction signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6016 19769 Ensembl ENSG00000143622 ENSMUSG00000028057 UniProt Q92963 P70426 RefSeq (mRNA) NM_006912 NM_001256820 NM_001256821 NM_001163310 NM_009069 RefSeq (protein) NP_001243749 NP_001243750 NP_008843 NP_001156782 NP_033095 NP_001390950 NP_001390951 NP_001390958 NP_001390959 NP_001390960 NP_001390962 NP_001390963 NP_001390964 NP_001390965 Location (UCSC) Chr 1: 155.9 – 155.91 Mb Chr 3: 88.62 – 88.64 Mb PubMed search [3] [4]
Wikidata
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Function

RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003).[supplied by OMIM]^[7]

Clinical significance

Mutations in RIT1 are associated to Noonan syndrome.^[8]

Interactions

RIT1 has been shown to interact with KLHL12^[9] and Merlin.^[10]