Rs16891982

In genetics, rs16891982, also known as F374L, is the name for a single nucleotide polymorphism found in the SLC45A2 gene. The SNP consists of two alleles: C (cytosine) and G (guanine).^[2] It is associated with skin tone and hair/eye color. It is a type of missense mutation.^[3]

SNP: rs16891982
Name(s)	F374L, c.1122C>G
Gene	SLC45A2
Chromosome	5
Region	Exon 5[1]
External databases
Ensembl	Human SNPView
dbSNP	rs16891982
HapMap	rs16891982
SNPedia	rs16891982

C allele homozygosity is associated with black hair in people of European descent, although those with this genotype are usually of non-European descent.^[2]

C/G allele heterozygosity is associated with black hair in people of European descent^[2]

G allele homozygosity is associated with light skin, hair, and eye color (European ancestry),^[4][5] those with this genotype also have a slightly higher susceptibility to melanoma.^[3]