S100A14

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.^[5]

S100A14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M0R
Identifiers
Aliases	S100A14, BCMP84, S100A15, S100 calcium binding protein A14
External IDs	OMIM: 607986; MGI: 1913416; HomoloGene: 10781; GeneCards: S100A14; OMA:S100A14 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,614,255 bp[1] End 153,616,986 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 90,434,163 bp[2] End 90,436,144 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx mucosa of transverse colon skin of abdomen oral cavity body of tongue skin of leg gums rectum gingival epithelium vulva Top expressed in esophagus lip skin of abdomen skin of external ear epidermis hair follicle skin of back pyloric antrum mucous cell of stomach left colon More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding chemokine receptor binding calcium ion binding Cellular component cell junction perinuclear region of cytoplasm extracellular exosome cytoplasm cytosol nuclear body plasma membrane Biological process positive regulation of monocyte chemotaxis response to lipopolysaccharide calcium ion homeostasis apoptotic process toll-like receptor 4 signaling pathway defense response to bacterium positive regulation of granulocyte chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57402 66166 Ensembl ENSG00000189334 ENSMUSG00000042306 UniProt Q9HCY8 Q9D2Q8 RefSeq (mRNA) NM_020672 NM_001163525 NM_001163526 NM_025393 RefSeq (protein) NP_065723 NP_001156997 NP_001156998 NP_079669 Location (UCSC) Chr 1: 153.61 – 153.62 Mb Chr 3: 90.43 – 90.44 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.^[6][7]