S100P

S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene.^[3][4][5]

S100P
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1J55, 1OZO, 2MJW
Identifiers
Aliases	S100P, MIG9, S100 calcium binding protein P
External IDs	OMIM: 600614; HomoloGene: 81743; GeneCards: S100P; OMA:S100P - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 6,693,878 bp[1] End 6,697,170 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium mucosa of urinary bladder palpebral conjunctiva olfactory zone of nasal mucosa bone marrow amniotic fluid periodontal fiber epithelium of nasopharynx pylorus testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding RAGE receptor binding metal ion binding calcium-dependent protein binding magnesium ion binding cadherin binding transition metal ion binding protein homodimerization activity Cellular component plasma membrane cell projection extracellular exosome membrane nucleus microvillus membrane cytoplasm extracellular region nuclear body secretory granule lumen Biological process response to organic substance endothelial cell migration neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6286 n/a Ensembl ENSG00000163993 n/a UniProt P25815 n/a RefSeq (mRNA) NM_005980 n/a RefSeq (protein) NP_005971 n/a Location (UCSC) Chr 4: 6.69 – 6.7 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca²⁺, also binds Zn²⁺ and Mg²⁺. This protein may play a role in the etiology of prostate cancer.^[5]

Interactions

S100P has been shown to interact with EZR^[6] and RAGE.^[7] The interactions between S100P and RAGE are disrupted by cromolyn^[8] and pentamidine.^[7]