SAE1

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.^[5][6][7][8]

SAE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y8Q, 1Y8R, 3KYC, 3KYD
Identifiers
Aliases	SAE1, AOS1, HSPC140, SUA1, UBLE1A, SUMO1 activating enzyme subunit 1
External IDs	OMIM: 613294; MGI: 1929264; HomoloGene: 4019; GeneCards: SAE1; OMA:SAE1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 47,113,274 bp[1] End 47,210,636 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A2|7 8.88 cM Start 16,054,159 bp[2] End 16,121,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence muscle layer of sigmoid colon stromal cell of endometrium left testis right testis gonad oocyte prefrontal cortex smooth muscle tissue Top expressed in ventricular zone epiblast primitive streak somite abdominal wall mandibular prominence neural tube maxillary prominence yolk sac tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin activating enzyme activity SUMO activating enzyme activity enzyme activator activity ligase activity protein C-terminus binding ubiquitin-like modifier activating enzyme activity protein binding ATP-dependent protein binding small protein activating enzyme binding protein heterodimerization activity Cellular component SUMO activating enzyme complex nucleus nucleoplasm cytoplasm Biological process protein sumoylation protein ubiquitination positive regulation of protein targeting to mitochondrion positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10055 56459 Ensembl ENSG00000142230 ENSMUSG00000052833 UniProt Q9UBE0 Q9R1T2 RefSeq (mRNA) NM_001145713 NM_001145714 NM_005500 NM_001285891 NM_001285892 NM_019748 RefSeq (protein) NP_001139185 NP_001139186 NP_005491 NP_001272820 NP_001272821 NP_062722 Location (UCSC) Chr 19: 47.11 – 47.21 Mb Chr 7: 16.05 – 16.12 Mb PubMed search [3] [4]
Wikidata
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Interactions

SAE1 has been shown to interact with SAE2, the protein product of the gene UBA2.^{[5][7][9][10]}