SAV1

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.^[5][6][7]

SAV1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DWV, 2YSB
Identifiers
Aliases	SAV1, SAV, WW45, WWP4, salvador family WW domain containing protein 1
External IDs	OMIM: 607203; MGI: 1927144; HomoloGene: 32517; GeneCards: SAV1; OMA:SAV1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 50,632,058 bp[1] End 50,668,306 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 70,011,786 bp[2] End 70,033,776 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte mucosa of paranasal sinus secondary oocyte nipple lactiferous duct olfactory zone of nasal mucosa Achilles tendon urethra body of pancreas superficial temporal artery Top expressed in gastrula spermatocyte intercostal muscle decidua interventricular septum calvaria arm upper arm triceps brachii muscle temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular adaptor activity identical protein binding Cellular component cytoplasm nucleus cytosol intracellular anatomical structure Biological process hair follicle development ventricular septum morphogenesis lung epithelial cell differentiation protein stabilization positive regulation of DNA-binding transcription factor activity regulation of stem cell population maintenance negative regulation of cardiac muscle cell proliferation regulation of organ growth positive regulation of fat cell differentiation hippo signaling intestinal epithelial cell differentiation signal transduction keratinocyte differentiation negative regulation of epithelial cell proliferation positive regulation of apoptotic process apoptotic process regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60485 64010 Ensembl ENSG00000151748 ENSMUSG00000021067 UniProt Q9H4B6 Q8VEB2 RefSeq (mRNA) NM_021818 NM_022028 RefSeq (protein) NP_068590 NP_071311 Location (UCSC) Chr 14: 50.63 – 50.67 Mb Chr 12: 70.01 – 70.03 Mb PubMed search [3] [4]
Wikidata
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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.^[7]