SC65

Endoplasmic reticulum protein SC65, also known as Leprecan-like protein 4 (LEPREL4) or nucleolar autoantigen No55, is a protein that in humans is encoded by the P3H4 gene.^[5]

P3H4
Identifiers
Aliases	P3H4, NO55, NOL55, SC65, LEPREL4, prolyl 3-hydroxylase family member 4 (non-enzymatic), prolyl 3-hydroxylase family member 4 (inactive)
External IDs	OMIM: 617419; MGI: 1913430; HomoloGene: 4713; GeneCards: P3H4; OMA:P3H4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,801,947 bp[1] End 41,812,604 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 100,299,282 bp[2] End 100,305,662 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium periodontal fiber tibia ventricular zone anterior pituitary right lobe of thyroid gland left adrenal cortex tendon of biceps brachii right adrenal gland body of pancreas Top expressed in calvaria molar epithelium of lens umbilical cord upper jaw body of femur supraoptic nucleus vestibular membrane of cochlear duct ascending aorta right ventricle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 10609 66180 Ensembl ENSG00000141696 ENSMUSG00000006931 UniProt Q92791 Q8K2B0 RefSeq (mRNA) NM_006455 NM_176830 NM_001378981 RefSeq (protein) NP_006446 NP_789800 NP_001365910 Location (UCSC) Chr 17: 41.8 – 41.81 Mb Chr 11: 100.3 – 100.31 Mb PubMed search [3] [4]
Wikidata
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Function

This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes.^[5]