Top Qs
Timeline
Chat
Perspective

ATXN8OS

Non-coding RNA in the species Homo sapiens From Wikipedia, the free encyclopedia

Remove ads

Ataxin 8 opposite strand, also known as ATXN8OS, is a human gene.[2]

Quick Facts Identifiers, Aliases ...
Remove ads

Function

SCA8 is an antisense transcript to the KLHL1 gene (homolog to the Drosophila KELCH gene); it does not itself appear to be protein coding. A cytidine, thymidine, guanosine (CTG) trinucleotide repeat expansion that is incorporated into the SCA8 but not the KLHL1 transcript causes spinocerebellar ataxia type 8. When the CTG expansion is present, a polyglutamine mutant protein is produced.[3] Presumably the expansion interferes with normal antisense function of this transcript.[2]

Remove ads

See also

References

Further reading

Loading content...
Loading content...
Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads