SCAMP3

Secretory carrier-associated membrane protein 3 is a protein that in humans is encoded by the SCAMP3 gene.^[5][6][7]

SCAMP3
Identifiers
Aliases	SCAMP3, C1orf3, secretory carrier membrane protein 3
External IDs	OMIM: 606913; MGI: 1346346; HomoloGene: 4164; GeneCards: SCAMP3; OMA:SCAMP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,255,979 bp[1] End 155,262,430 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 89,084,780 bp[2] End 89,090,072 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex stromal cell of endometrium apex of heart left ventricle skin of leg mucosa of transverse colon skin of abdomen gastrocnemius muscle Top expressed in yolk sac right kidney zygote muscle of thigh external carotid artery lens proximal tubule lip internal carotid artery superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase binding Cellular component integral component of membrane extracellular exosome intracellular membrane-bounded organelle membrane Golgi membrane Golgi apparatus trans-Golgi network membrane recycling endosome membrane Biological process protein transport post-Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10067 24045 Ensembl ENSG00000263290 ENSG00000116521 ENSMUSG00000028049 UniProt O14828 O35609 RefSeq (mRNA) NM_005698 NM_052837 NM_011886 NM_001309909 NM_001309910 RefSeq (protein) NP_005689 NP_443069 NP_001296838 NP_001296839 NP_036016 Location (UCSC) Chr 1: 155.26 – 155.26 Mb Chr 3: 89.08 – 89.09 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

SCAMP3 has been shown to interact with NEDD4.^[8]