SCAND1

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.^[5][6][7][8]

SCAND1
Identifiers
Aliases	SCAND1, RAZ1, SDP1, SCAN domain containing 1
External IDs	OMIM: 610416; MGI: 1343132; HomoloGene: 10642; GeneCards: SCAND1; OMA:SCAND1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 35,953,617 bp[1] End 35,959,472 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,153,766 bp[2] End 156,154,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon olfactory zone of nasal mucosa right adrenal gland right adrenal cortex left adrenal cortex anterior pituitary right lobe of liver apex of heart right uterine tube gastric mucosa Top expressed in granulocyte tibiofemoral joint seminiferous tubule yolk sac muscle of thigh medial ganglionic eminence calvaria internal carotid artery right kidney external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription coactivator activity protein binding identical protein binding DNA binding Cellular component nucleus Biological process regulation of transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51282 19018 Ensembl ENSG00000171222 ENSMUSG00000046229 UniProt P57086 Q2M4I6 RefSeq (mRNA) NM_033630 NM_016558 NM_001385710 NM_020255 RefSeq (protein) NP_057642 NP_361012 NP_064651 Location (UCSC) Chr 20: 35.95 – 35.96 Mb Chr 2: 156.15 – 156.15 Mb PubMed search [3] [4]
Wikidata
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Function

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 amino acids originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.^[8]

Interactions

SCAND1 has been shown to interact with MZF1.^[5]